It's the second helicopter-aided inmate escape in Quebec province in two years.
Provincial police said the helicopter headed west from the Orsainville Detention Center after the escape.
"We (are working with) a few partners like the airports of Quebec City and surrounding areas, the military bases, and of course there's a ground search in the event that the helicopter is located," said police spokeswoman Audrey-Anne Bilodeau.
Police identified the inmates on Twitter as Yves Denis, Denis Lefebvre and Serge Pomerleau and told anyone who sees them to not approach them and immediately contact police.
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